The Central Committee on Research involving Human Subjects (CCMO Central Committee on Research involving Human Subjects (Central Committee on Research involving Human Subjects )), the Ministry of Health, Welfare and Sport (VWS Ministry of Health, Welfare and Sport (Ministry of Health, Welfare and Sport )), and the Ministry of Infrastructure and Water Management (IenW Ministry of Infrastructure and Water Management (Ministry of Infrastructure and Water Management )), require mandatory submission of periodic reports and notifications with regard to current gene therapy research. These reports must also be submitted through the Gene Therapy Office.